4 Side Effects of Stopping Creatine

Creatine monohydrate is a nutritional supplement, available either as powder or creatine pills, used by many athletes in an effort to boost performance and muscle growth. But it's also produced naturally by your body in various organs, including your pancreas and kidneys.

While you're supplementing with creatine, your total serum creatine levels and the amount of creatine stored in your muscles increase, according to WebMD. But what happens if you stop taking creatine? These levels drop, which might cause some side effects, including fatigue, muscle weakness, weight loss or increased bloating and decreased natural creatine production.

Stopping creatine supplementation might cause fatigue, and if you have chronic fatigue syndrome, or CFS, stopping creatine might make your symptoms worse.

To understand this better, it's important to know what creatine does and how creatine gives you energy. About 5 percent of the creatine in your body is stored in your brain to assist with the energy-producing process involved in the production of brain hormones and neurotransmitters.

However, when total body creatine levels are reduced after you stop creatine supplementation, your brain might have a temporary lapse in the production of these compounds, leaving you fatigued.

Most of the creatine in your body is stored in your skeletal muscles and used in the energy-producing metabolic pathways involved in movement and muscle contraction, according to Drugs.com.

Among the benefits of creatine, it increases your muscles' ability to produce large amounts of energy rapidly, which can increase your muscle strength and workout intensity.

When creatine levels in your muscles drop, so does your ability to produce energy, especially during exercise. This might leave your muscles feeling weak and might decrease muscle strength and exercise intensity.

With every molecule of creatine that's stored in your skeletal muscles, several molecules of water are stored with it, a process known as muscle hydration. Muscle hydration results in your muscles feeling and looking more full and also can make you gain weight. The water weight gain you might experience while supplementing with creatine is sometimes falsely attributed to muscle gain.

When you stop supplementing with creatine, your muscles will not hold as much water, making you lose weight, sometimes up to 5 to 7 pounds, in the first several days to a week after stopping creatine.

One of the possible effects of creatine supplementation — particularly taking too much creatine — is the overdependence on external sources of creatine, according to an August 2017 study in ‌International Immunopharmacology‌.

When your body detects large amounts of creatine in your system, it might signal your organs to slow or stop production because your body is tricked into thinking it is overproducing creatine.

Once you stop creatine supplementation, your body might not be able to begin synthesizing creatine immediately. Although there is no evidence that suggests creatine supplementation will cause permanent damage to the organs that synthesize creatine, a short-term decrease in production following creatine supplementation has been observed.